Escharotic Therapy

HPV video by Dr. Nick LeRoy

Escharotic Treatment for cervical dysplasia involves the topical application of a solution of zinc chloride and Bloodroot (Sanguinaria canadensis) to the uterine cervix and/or vagina. This solution remains on the cervix and adjacent tissues for only about 90 seconds, after which it is removed. This solution is termed an escharotic because of its ability to kill abnormal (dysplastic) or HPV-infected cells causing the formation of an "eschar". For additional information see Dr. Nick's HPV Video above.

An eschar is a scab-like layer of dead or diseased tissue that will slough off within several days of formation. The eschar is the dead abnormal tissue. The following are examples of cervical eschars that have formed after the application of zinc chloride and Bloodroot:

Cervical eschar This image demonstrates an eschar on the lower cervix after the application of zinc chloride and bloodroot. Note that although the entire cervix was covered with the escharotic solution, only the small area at the lower cervix is affected.
Sloughing of cervical eschar
This image shows a thin layer of dead cells in the process of sloughing off after the first application of the escharotic treatment for cervical dysplasia. Because cervical biopsies were all negative in this case, these dead cells likely represent HPV-infected cells rather than dysplastic cells. Treatment in this case was initiated because paps were consistently coming back abnormal despite "normal" colposcopies.
Vaginal wall eschar
This is a case in which the vaginal walls were dysplastic (see yellow/white staining). Dr. LeRoy is finding that many cases involve some vaginal wall dysplasia and may explain why paps are coming back abnormal while cervical biopsies are negative.
Lower cervical eschar
This is a classic eschar on the lower cervix.
Cervical eschar
This case demonstrates a rather large area of abnormality.
Upper outer cervical eschar
Here is an eschar on the upper, outer cervix at 10:00.
Lower cervical eschar
Another lower cervical eschar. Note there is also involvement in the cervical canal.
Eschar at cervical os
This eschar is at the border of the cervical canal in the area known as the transformation zone.
Lower cervical eschar
Lower cervical eschar.


The goal of escharotic therapy is to remove diseased, HPV-infected tissue while maximizing the likelihood that healthy cells will replace the one being removed.
This replacement of HPV-infected, dysplastic cells with healthy, normal cells is accomplished with the oral or systemic portion of therapy.

Systemic therapy consists of a plant-based diet and supplements that are proven to reverse dysplasia and assist in clearing HPV. The following images demonstrate the formation and elimination of an eschar with healthy, non-diseased tissue:

Lower cervical eschar This is an image of the cervix of a 24 year-old with high risk HPV and atypia. The eschar on the lower cervix occurred after 3 applications of the escharotic solution.
Eschar much smaller
One week later the eschar is almost gone, replaced with normal, healthy tissue. This patient had two more treatments and her pap was normal with undetectable HR-HPV.


The application of the escharotic solution is usually performed 1-2 times per week or as tolerated by the patient.
Dr. LeRoy also performs this treatment 2 or 3 days in a row, at about once per month, for patients coming from further away. This minimizes the cost of travel while still obtaining successful results. Most women will obtain a normal pap without evidence of HPV in 8-12 total treatments.

The addition of Curcumin

Because curcumin has been shown in research to counteract the proliferative effects of estradiol while inducing the death of cervical cancer cells, Dr. LeRoy began adding it to his oral supplement regimen as well as to the escharotic solution in 2013. The fact that researchers at Staten Island University Hospital have found a curcumin-containing vaginal cream to be effective at killing cells with HPV factored into Dr. LeRoy's decision. The following images demonstrate the use of curcumin in the escharotic solution:

HPV & cervicitis
This image is the cervix of a 42 year-old with CIN2 and HR-HPV. The redness is due to inflammation associated with cervicitis. This was a difficult case that was responding slowly, in part, due to the patient's age as well as the inflammation. This was a week after the seventh application of the escharotic and a decision was made to add curcumin to the solution in an attempt to diminish the cervicitis as well as kill HPV-infected cells.
Curcumin with escharotic
This is the cervix after the application of the escharotic with curcumin (i.e. zinc chloride, bloodroot & curcumin).
Decrease in cervicitis
Notice the decrease in redness one week after the above images. After disappointing results with the first seven treatments, only one treatment with the addition of curcumin has resulted in a substantial improvement.


Is there scarring or damage to the cervix by using escharotic therapy?

Absolutely not. And furthermore...never. Dr. LeRoy has been using escharotic therapy since 1995 and not only has there never been an adverse outcome, there has been a re-modeling of the cervix in cases where the cervix is not healthy at the onset of therapy. In other words, the cervix often looks better after escharotic therapy. The following case demonstrates this finding:


Severe cervicitis
This is the initial visit of a 35-year-old woman with CIN2 and a high-risk HPV. Note the presence of Nabothian cysts at the upper left area of the cervix--a hallmark of cervicitis (chronic inflammation).
CIN2 after escharotic This is after the application of the escharotic solution on the first visit. Areas of inflammation will often stain similarly to dysplastic and HPV-infected cells (i.e. the area that is staining in this image is not likely all dysplasia; but rather, much of it is inflammation with areas of dysplasia/HPV-infection contained within).
CIN2 improvement
This is after escharotic application with curcumin added to solution at the fourth treatment. Note the area that is staining is smaller than at the first visit above.
Mild cervicitis At the tenth visit the area of inflammation is much smaller. The area that was staining with the escharotic was much smaller as well (not shown here).
Normal healthy cervix This is the last treatment. Note the cervicitis and Nabothian cysts are absent. Follow-up pap was normal and HR-HPV undetected. This is now a normal, healthy cervix.

Cervical Deformity with Conventional Treatment

Whether there is scarring with escharotic therapy is probably one of the more frustrating questions that is often asked because it is so far from the truth. It is conventional procedures such as the LEEP that can cause deformity of the cervix as well as scarring. It has been found that even just one LEEP can more than triple the risk of spontaneous abortion; and yet women are perfectly willing to undergo this barbaric hacking away at their cervices with little regard for consequences. The following image is of a woman who had what her doctor characterized as a LEEP many years ago; however, it was clearly an aggressive removal of tissue that never grew back:

LEEP This is many years after a LEEP in a woman over fifty years-of-age. Note that there is a large area of removed tissue adjacent to the endocervical canal that has never grown back.

With an experienced physician this never happens with escharotic therapy.


LEEP
This is not what a cervix is supposed to look like and yet this is considered modern medicine--the standard-of-care in treating cervical dysplasia.

Cost of Treatment and Appointment Information


Click here for Before and After Treatment Pics